香豆素是一种带有香味和灼觉的结晶体,自1820年从顿加香豆(Tonka bean)中分离出后,作为香精应用于食物、烟草和化妆品已有100多年了。 Hazelton等曾报导香豆素在大鼠的90天实验中,50和250ppm对体重增长、饲料效价和器官病理学没有影响;2,500 ppm时,体重增长受抑制,肺肿大和肝组织损伤等。在二年的实验中,1,000 ppm未见有害作用,但在狗的130～330天,25 mg/kg/天的实验中,有肝损伤。近来报导香豆素的代谢有种系差异,为探讨对人的毒性反应,必需找一种代谢方式接近于人的动物来进行研究。经预试验表明,香豆素以50或100 mg/kg/天的剂量给予狒狒, Coumarin, a scent and burning sensation, has been used as a fragrance for food, tobacco and cosmetics since 1820 after it was isolated from Tonka bean. Hazelton et al. Reported that coumarin had no effect on body weight gain, feed titer and organ pathology at 50 and 250 ppm in rats during a 90-day experiment; inhibited body weight gain at 2,500 ppm, lung enlargement, and liver tissue damage. In two years of experiments, 1,000 ppm had no adverse effects, but liver damage was observed in dogs at 130 to 330 days at 25 mg / kg / day. It has recently been reported that there are germ line differences in the metabolism of coumarin. In order to explore the toxic response to humans, it is necessary to find a metabolic approach close to human animals for research. Pre-tests have shown that coumarin is administered to baboons at a dose of 50 or 100 mg / kg / day,