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胰岛素样生长因子 - 1(IGF - 1)是一类既具有促进细胞分化和增殖活性又具有胰岛素样作用的多肽 .IGF- 1与胰岛素原有 6 0 %的结构同源性 .对小鼠、大鼠和人的成骨细胞的研究结果显示 :IGF - 1和胰岛素可通过促进骨祖细胞及成骨样细胞的增殖和分化等多种机制而发挥保护骨量的作用 .IGF - 1和胰岛素的作用受IGF结合蛋白(IGFBP)、激素和细胞因子的调节
Insulin - like growth factor - 1 (IGF - 1) is a kind of polypeptide with both promoting cell differentiation and proliferation activity and insulin - like activity.IGF - 1 has 60% structural homology with insulin, The results of rat and human osteoblasts show that IGF - 1 and insulin exert the function of protecting bone mass through promoting proliferation and differentiation of osteoprogenitors and osteoblast - like cells.IGF - 1 and insulin The role of regulation of IGF binding protein (IGFBP), hormones and cytokines