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目的 论对慢性萎缩性胃炎患者实施整体护理对患者心理和生活质量的影响。方法将2019年4月至2020年8月到我院进行治疗的72例慢性萎缩性胃炎患者，按照随机方法分为观察组和对照组，两组患者均为36例。对患者进行护理的时候，分别按照整体护理方法和常规护理方法开展不同的干预，并对不同护理之后的治疗有效率、临床症状恢复时间、焦虑、抑郁情绪以及睡眠质量改善情况、并发症的发生率、生活质量等相关的情况进行统计和比较。结果①观察组（34例，占94.44%）经整体护理后的治疗有效率比对照组（27例，占75.00%）经常规护“,”Objective To discuss the impact of holistic care for patients with chronic atrophic gastritis on the psychology and quality of life of the patients.Methods A total of 72 patients with chronic atrophic gastritis who came to our hospital for treatment from April 2019 to August 2020 were randomly divided into an observation group and a control group，with 36 patients in both groups.When nursing patients，different interventions were carried out according to overall nursing methods and routine nursing methods，and the treatment efficiency，clinical symptom recovery time，anxiety，depression and sleep quality improvement after different nursing care，and the occurrence of complications were analyzed.Statistics and comparisons of related conditions such as rate and quality of life.Results(1)The treatment efficiency of the observation group(34 cases，accounting for 94.44%)after overall nursing was higher than that of the control group(27 cases，accounting for 75.00%)after routine nursing(P＜0.05).(2)After the overall nursing，the recovery time of belching symptoms，epigastric distention symptoms，bloating symptoms，weakness symptoms and pain symptoms in the observation group was shorter than that in the control group(P＜0.05).(3)Before nursing，there was no significant difference in SAS score，SDS score and PSQI score between the two groups(P＞0.05).After nursing，although there were improvements，the improvement in the observation group was more ideal(P＜0.05).(4)The incidence of complications in the observation group(4 cases，accounting for 11.11%)after overall care was lower than that in the control group(13 cases，accounting for 36.11%)，which was consistent with the routine care(P＜0.05).(5)Before nursing，there was no significant difference in the quality of life scores between the two groups(P＞0.05).After nursing，both groups were improved，but the improvement effect in the observation group was more significant(P＜0.05).Conclusion For patients with chronic atrophic gastritis，implementing holistic nursing at the same time can improve the therapeutic effect of patients.This nursing method can change the negative emotions of patients，eliminate clinical symptoms and signs，improve sleep conditions，and reduce the influence of complications to the body can improve the quality of life in all aspects，can be accepted and recognized by patients，and has the value of recommendation.