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自1980年10月以来用放射免疫双抗法测定了14～43周正常孕妇血清AFP 794例、羊水AFP434例,建立了本实验室各孕周血清及羊水AFP的测定值。并对85例异常妊娠(胎儿先天异常17例、多胎31例、死胎25例、滋养叶细胞肿瘤12例)作了测定,并报告了测定结果。对411例各孕周羊水/母血清AFP的比值作了测定,两者的比值是随着妊娠进展而逐渐下降的。从14～15孕周时的318,下降到36～43孕周时近于1.95例足月分娩孕妇中发现脐血清AFP值高者,其母血清AFP值也相对增高,间接证明母血清AFP来自胎儿。
Since October 1980, radioimmunoassay was used to measure the serum AFP in 714 pregnant women and 1494 pregnant women with AFP434 cases of amniotic fluid. Eighty-five cases of abnormal pregnancy (17 cases of congenital anomalies, 31 cases of multiple births, 25 cases of stillbirth and 12 cases of trophoblastic tumor) were measured and the results were reported. The ratio of amniotic fluid / serum AFP in 411 cases of each gestational week was determined, and the ratio of them decreased gradually with the progress of pregnancy. From 14 to 15 gestational weeks when the 318, down to 36 to 43 gestational weeks when nearly 1.95 cases of full-term delivery of pregnant women found that cord blood serum AFP values were higher, the mother’s serum AFP values were relatively increased, indirectly proves that the serum from the AFP from fetus.