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目的:观察乙酰半胱氨酸注射液(NAC)治疗慢性重型乙型肝炎的疗效。方法:收治的慢性重型肝炎早、中期分为对照组(57例),治疗组(58例),对照组给予一般支持治疗、门冬氨酸钾镁,血浆或白蛋白等基础治疗及促肝细胞生长素100mg/d。治疗组在对照组的基础上加用乙酰半胱氨酸注射液8g/d静脉滴注,疗程30d,并于用药前,用药后15d,30d分别抽血查肝功,凝血酶原活动度。结果:治疗组血清总胆红素(TBil),凝血酶原活动度(PTA)的改善程度明显优于对照组,差异有统计学意义。结论:乙酰半胱氨酸注射液能明显降低患者血清TBil,提高PTA,对重型肝炎的治疗有较好的帮助。
Objective: To observe the efficacy of acetylcysteine injection (NAC) in the treatment of chronic severe hepatitis B Methods: The patients with chronic severe hepatitis were divided into control group (57 cases) and treatment group (58 cases) in the early and middle stages. Patients in the control group received general supportive therapy, potassium magnesium and aspartate, plasma or albumin, Cytosin 100mg / d. On the basis of the control group, the treatment group was treated with 8g / d of acetylcysteine injection intravenously for 30 days. Before the treatment and 15d and 30d after the treatment, blood was collected to check the liver function and prothrombin activity. Results: The improvement of serum total bilirubin (TBil) and prothrombin activity (PTA) in the treatment group was significantly better than that in the control group, the difference was statistically significant. Conclusion: Acetylcysteine injection can significantly reduce the patient serum TBil, improve PTA, the treatment of severe hepatitis have a better help.