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近年来铂络合物抗癌作用的研究受到重视,二价铂络合物中顺-[Pt(NH_3)_2Cl_2]不仅能抑制多种动物实验肿瘤,且对人体泌尿生殖系统、头颈部以及软组织恶性肿瘤有显著疗效,但还存在着缓解期短、毒性较高的缺点。需进一步研究铂络合物结构和抗癌功能的关系。最近发现属四价铂的二羟基丙二酸根二氨合铂具有很强的抑制W-256癌的能力,测定其晶体结构和分子结构,对研究四价铂络合物抗癌作用的构效关系将会有重要意义。
In recent years, the research of anti-cancer effect of platinum complexes has been paid more attention. Cis- [Pt (NH 3) 2 Cl 2] in divalent platinum complexes not only inhibits the tumor growth in a variety of animal experiments, but also inhibits the human urogenital system, head and neck, Soft tissue malignancies have a significant effect, but there are still shortcomings, high toxicity shortcomings. The relationship between the structure of platinum complexes and anti-cancer function needs to be further studied. Recently, tetravalent platinum dihydroxyl malonate diammine platinum has been shown to have a strong ability to inhibit W-256 carcinoma, its crystal structure and molecular structure were determined, and its effect on studying the anticancer effect of the tetravalent platinum complex Relationship will be of great significance.