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目的探讨心房快速起搏对兔心房有效不应期(effective refractory period,ERP)和心肌组织场电位时程(field potential duration,FPdur)的影响。方法成年新西兰兔40只,以500次/min行快速起搏并测量ERP,根据起搏时间分为5组,0,4,8,12,24h组各8只。起搏结束时开胸取心,应用微电极阵列技术记录场电位形态及Fpdur,比较各组心房组织FPdur与ERP变化趋势。结果 8h组ERP缩短为(82.11±1.74)ms,24h组缩短至(80.09±2.18)ms,与0h组比较差异均有统计学意义(P<0.05);8h组FPdur延长为(121.18±3.55)ms,24h组延长至(85.91±5.4)ms,与0h组比较差异有统计学意义(P<0.05);R-R间期在起搏4h后缩短至最低,振幅在起搏后12h降至最低,搏动频率在起搏后4h降至最低,与0h组比较差异均有统计学意义(P<0.05)。结论心房颤动时心房ERP缩短,FPdur延长,微电极阵列技术可对心房颤动时的电重构提供准确电生理变化信息。
Objective To investigate the effect of rapid atrial pacing on the effective refractory period (ERP) and field potential duration (FPdur) in rabbits. Methods Forty adult New Zealand white rabbits were randomly divided into 5 groups according to pacing time and 8 rats in each of 0, 4, 8, 12 and 24 hours group. At the end of pacing, thoracotomy was performed. The field potential patterns and Fpdur were recorded by microelectrode array technology. The changes of FPdur and ERP in each group were compared. Results The ERP of 8h group was (82.11 ± 1.74) ms shortened to (80.09 ± 2.18) ms in 24h group, the difference was statistically significant compared with 0h group (P <0.05) (P <0.05). The RR interval shortened to the lowest at 4h after pacing, the amplitude decreased to the lowest at 12h after pacing, The frequency of beating was reduced to the lowest at 4h after pacing, and the difference was statistically significant compared with 0h group (P <0.05). Conclusions Atrial fibrillation shortens the atrial ERP and prolongs FPdur. The microelectrode array technique can provide accurate electrophysiological information on the electrical remodeling during atrial fibrillation.