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目的探讨三氯乙烯(TCE)职业接触对尿中3种小分子蛋白水平的影响。方法以112名TCE接触工人和70名对照作为调查对象,收集职业史、年龄、性别、吸烟和饮酒等信息。收集班后尿,测定三氯乙酸(TCA)水平及α1微球蛋白(α1-M)、β2微球蛋白(β2-M)、视黄醇结合蛋白(RBP)的水平。结果3种小分子蛋白α1-M、β2-M、RBP水平在两组调查对象中比较,差异均无统计学意义。以作业工龄、TCE浓度、尿中TCA水平分组后,作业工龄≥1.9a的工人α1-M水平明显高于对照组,差异有统计学意义(P<0.05);高TCE浓度(198.0～257.0mg/m3)组及尿中TCA水平≥50mg/L组的工人RBP水平均明显高于对照组,差异有统计学意义(P<0.05)。结论长时间和高水平TCE职业接触可致作业工人尿中α1-M、RBP水平增高。
Objective To investigate the effects of trichlorethylene (TCE) occupational exposure on the levels of three small molecules in urine. Methods A total of 112 TCE exposed workers and 70 controls were included in the survey. Occupational history, age, gender, smoking and drinking were collected. After class urine was collected, TCA levels and α1-microglobulin (α1-M), β2 microglobulin (β2-M), retinol binding protein (RBP) levels were determined. Results There was no significant difference in the levels of α1-M, β2-M and RBP between the two groups. The levels of α1-M in working age ≥1.9a were significantly higher than those in control group after working age, TCE concentration and urinary TCA level (P <0.05). High TCE concentration (198.0 ~ 257.0mg / m3) and urine RBP levels of workers with TCA level ≥50mg / L were significantly higher than those of the control group (P <0.05). Conclusion Long-term and high-level occupational exposure to TCE can cause urinary α1-M and RBP levels in workers.