为探讨在高原或仿高原环境下高强度运动的心脏适应机制，通过动物实验模拟高原运动心脏，观察了心肌组织中ＣｕＺｎ－ＳＯＤ ｍＲＮＡ的表达情况。结果表明，在海拔５０００米环境下，大鼠６％负重游泳１０分钟，常压休息１０分钟，重复３次，在运动后３０分钟和２４小时，心肌ＣｕＺｎ－ＳＯＤ ｍＲＮＡ的表达出现两个高峰，分别比对照组升高了４７％和１１２％；而大鼠在单独低压氧环境下不运动，只在缺氧后３０分钟时有ＣｕＺｎ－ＳＯＤ ｍＲＮＡ的表达增高。结果提示：与经典的缺血预处理类似，在高原或仿高原环境下进行高强度训练，很可能是一种由心肌缺血和缺氧等因素所诱发的“运动预处理”现象。 In order to explore the mechanism of cardiac adaptation to high-intensity exercise in the plateau or plateaus, the heart of the plateau was simulated by animal experiments and the expression of CuZn-SOD mRNA in myocardium was observed. The results showed that at a altitude of 5 000 m, 6% of rats had a swimming load of 10% for 10 minutes, resting for 10 minutes and 3 times for repetition. At 30 and 24 hours after exercise, CuZn-SOD mRNA expression showed two peaks, Respectively, increased by 47% and 112% respectively compared with the control group. However, the rats did not exercise in hypoxia alone, and the expression of CuZn-SOD mRNA increased only 30 minutes after hypoxia. The results suggest that, similar to classical ischemic preconditioning, high-intensity training in plateau or imitation plateau may be a “preconditioning” phenomenon induced by factors such as myocardial ischemia and hypoxia.