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用氢清除法和电子自旋共振等方法测定了５／６肾切除大鼠术３０～１２０天残肾的有关指标，发现饲以普通饲料的Ⅱ组大鼠残肾组织皿流量和氧自由基含量显著增加，抗氧化能力显著下降，肾功能进行性恶化，残肾炎性细胞浸润和纤维化显著；饲以大剂量维生素Ｅ的Ⅲ组大鼠，残肾血流量也显著增加，但氧自由基含量无显著增加，抗氧化能力无降低，肾功能和形态损害显著轻于Ⅱ组，动物死亡率显著低于Ⅱ组。提示残肾高灌注引起的氧自由基增高在残肾的进行性毁损中起有重要作用。
Hydrogen scavenging method and electron spin resonance and other methods were measured 5/6 nephrectomy in 30 to 120 days residual kidney related indicators and found to feed the normal diet group Ⅱ rats residual kidney tissue flow and oxygen free radicals Significantly increased the antioxidant capacity decreased significantly worsening renal function, residual renal cell infiltration and fibrosis significantly; feeding high-dose vitamin E group Ⅲ rats, residual renal blood flow was also significantly increased, but the oxygen free radicals No significant increase in the content, no reduction in antioxidant capacity, renal function and morphological damage was significantly lighter than the group Ⅱ, animal mortality was significantly lower than the group Ⅱ. Prompted residual renal hyperperfusion caused by increased oxygen free radicals in the residual damage of the kidney plays an important role.