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目的:观察苷必妥治疗慢性乙型肝炎及活动性肝硬化的临床疗效。方法:治疗组、对照组各60例,给予常规扩肝药物,治疗组加用苷必妥2mg,每日1次肌注。疗程3个月。结果:疗程结束时,治疗组ALT、SB复常率明显优于对照组(P<0.01),HBeAg和HBV-DNA的阴转率分别为47.5％和43.6％,而对照组则分别为15.4％和5.4％,两组之间有显著性差异(?)<0.01)、治疗组活动性肝硬化患者的血清Ⅲ型前胶原和单胺氧化酶的复常率明显优于对照组(P<0.01)。结论:苷必妥确有增强机体免疫功能和特异性抑制乙肝病毒增殖的作用,同时在一定程度上促进肝细胞再生的功能,对肝的纤维化也有一定的抑制作用
Objective: To observe the clinical efficacy of glycyrrhizin in the treatment of chronic hepatitis B and active cirrhosis. Methods: The treatment group and the control group of 60 cases, given conventional hepatic drugs, the treatment group plus glycyrrhizin 2mg, 1 intramuscular injection daily. Course of 3 months. Results: At the end of treatment, the normalization rate of ALT and SB in the treatment group was significantly higher than that in the control group (P <0.01). The negative conversion rates of HBeAg and HBV-DNA were 47.5% and 43.6% respectively, while those in the control group were 15.4% And 5.4%, respectively. There was significant difference between the two groups (?) <0.01). The normalization rate of serum type Ⅲ procollagen and monoamine oxidase in patients with active cirrhosis was significantly better than that of the control group (P <0.01). Conclusion: Glycosides can enhance the immune function and specifically inhibit the proliferation of hepatitis B virus, and at the same time promote the function of hepatocyte regeneration to a certain extent, and also inhibit the fibrosis of liver