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目的探讨新生儿窒息血清神经元特异性烯醇化酶(NSE)的变化及临床意义。方法 31例窒息新生儿中,轻度窒息20例,重度窒息11例,胎龄37～41周,取生后24～48h内(治疗前)和第7～10天(治疗后)静脉血2ml,用双抗体夹心酶联免疫吸附法测血清NSE。结果治疗前重度窒息组和轻度窒息组血清NSE分别为(62.53±18.03)μg/L和(41.40±13.12)μg/L,均显著高于对照组(25.72±8.79)μg/L(P<0.01),重度组NSE较轻度组显著增高(P<0.01);治疗后轻度、重度组NSE均显著下降(P<0.01),轻度组恢复正常,重度组较治疗前有显著下降(P<0.01),但仍高于对照组和轻度组(P<0.01)。结论血清NSE可作为判断窒息后缺氧性脑损伤的有效指标。
Objective To investigate the changes and clinical significance of neonatal asphyxia serum neuron specific enolase (NSE). Methods Twenty-one neonates with asphyxia underwent asphyxia in 20 cases, severe asphyxia in 11 cases, gestational age 37-41 weeks, within 24-48 hours after birth (before treatment) and 7-10 days (after treatment) Serum NSE was measured by double antibody sandwich enzyme-linked immunosorbent assay. Results The serum levels of NSE in severe asphyxia group and mild asphyxia group were (62.53 ± 18.03) μg / L and (41.40 ± 13.12) μg / L before treatment, respectively, which were significantly higher than those in control group (25.72 ± 8.79 μg / L, P < 0.01). The NSE in severe group was significantly higher than that in mild group (P <0.01). The NSE in mild group and severe group were significantly decreased (P <0.01), mild group returned to normal, P <0.01), but still higher than the control group and mild group (P <0.01). Conclusion Serum NSE can be used as an effective index to judge hypoxic brain injury after asphyxia.