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复发性流产(recurrent spontaneous abortion,RSA)是妊娠中常见的临床并发症之一,也是一直困扰医生和患者的一个难题,RSA不仅对患者的身体健康造成了危害,还严重影响了他们的家庭幸福。RSA是一种多因素疾病,病因复杂,其发病受遗传因素,环境因素及生活方式(如饮酒,咖啡及吸烟)等多方面的共同影响。近年来,有报道认为氧化应激(oxidative stress,OS)是RSA发病的高危因素之一,其中谷胱甘肽S-转移酶(glutathione S-transferases,GSTs)是体内氧化/抗氧化系统的重要成员,在体内活性氧产物(reactive oxygen species,ROS)的代谢中发挥重要作用。若GSTs的表达或功能出现异常,将会导致胚胎及胎盘暴露于内源性及外源性有害物质的损伤而导致流产。现将GST基因与RSA发病的相关性研究做一综述。
Recurrent spontaneous abortion (RSA) is one of the common clinical complications in pregnancy and also a problem that plagued doctors and patients. RSA not only harms patients’ health, but also seriously affects their family happiness . RSA is a multifactorial disease with complex causes. Its morbidity is affected by many factors such as genetic factors, environmental factors and lifestyle (such as drinking, coffee and smoking). In recent years, it has been reported that oxidative stress (OS) is one of the risk factors for RSA. Glutathione S-transferases (GSTs) are important in vivo oxidation / antioxidant system Members play an important role in the metabolism of reactive oxygen species (ROS) in the body. Abnormalities in the expression or function of GSTs can result in abortion as a result of exposure of embryos and placenta to endogenous and exogenous harmful substances. Now GST gene and RSA incidence of the study to do a review.