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细胞间粘附分子-1(ICAM-1)在炎症和免疫反应中起重要作用,sICAM-1可以作为许多炎症疾病病情观察的重要免疫学指标。本文拟在探讨病毒性肝炎患者血清 sICAM-1水平,及其与患者病情、肝功能的关系。资料与方法用酶联免疫法检测7例正常人和39例病毒性肝炎患者血清 sICAM-1水平,试剂由德国 Boehringer Mannheim 公司提供。结果与讨论1.结果急性肝炎和慢性肝炎患者血清 sICAM-1分别为975.93±322.51ng/ml 和833.08±490.59ng/ml,均明显高于正常人217.86±30.26ng/ml。急性肝炎患者血清 sICAM-1水平与其血清 ALT、AST 和 TSB 均呈明显正相关,P 值均小于0.05。轻度、中度和重度慢性病毒性肝炎患者血清 sICAM-1分别为367.9±118.5ng/ml、613.9±128.9ng/ml 和1273.0±404.4ng/ml,均
Intercellular adhesion molecule-1 (ICAM-1) plays an important role in inflammation and immune response, and sICAM-1 can be used as an important immunological indicator for the observation of many inflammatory diseases. This article intends to explore the serum of patients with viral hepatitis sICAM-1 levels, and its relationship with the patient’s condition, liver function. Materials and Methods Serum levels of sICAM-1 were measured by enzyme-linked immunosorbent assay in 7 normal subjects and 39 viral hepatitis patients. The reagents were supplied by Boehringer Mannheim AG in Germany. Results and Discussion 1. Results Serum sICAM-1 levels in patients with acute hepatitis and chronic hepatitis were 975.93 ± 322.51ng / ml and 833.08 ± 490.59ng / ml, respectively, which were significantly higher than 217.86 ± 30.26ng / ml in normal subjects. Serum levels of sICAM-1 in patients with acute hepatitis were positively correlated with serum ALT, AST and TSB, P values were less than 0.05. The serum sICAM-1 levels of patients with mild, moderate and severe chronic viral hepatitis were 367.9 ± 118.5ng / ml, 613.9 ± 128.9ng / ml and 1273.0 ± 404.4ng / ml respectively