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目的探讨血清孕酮和β-人绒毛膜促性腺激素(β-HCG)联合检测在异位妊娠早期诊断中应用。方法应用化学发光法分别检测45例异位妊娠(异位妊娠组)和55例正常宫内妊娠(正常妊娠组)妇女血清中孕酮和β-HCG的水平,比较两组妊娠4~6周血清孕酮和β-HCG水平变化。结果异位妊娠组第4周β-HCG水平与正常妊娠组比较差异无统计学意义(P>0.05),孕酮水平显著低于正常妊娠组(P<0.05),第5、6周血清孕酮和β-HCG水平均显著低于正常妊娠组(P<0.05);孕酮和β-HCG联合检测符合率显著高于单独测定β-HCG,且可显著缩短确诊时间(P<0.05)。结论血清孕酮和β-HCG联合检测可早期快速诊断异位妊娠,减少漏诊和误诊的发生,值得推广应用。
Objective To investigate the combination of serum progesterone and β-human chorionic gonadotropin (β-HCG) in the early diagnosis of ectopic pregnancy. Methods The serum levels of progesterone and β-HCG in 45 ectopic pregnancy (ectopic pregnancy group) and 55 normal uterine pregnancy (normal pregnancy group) women were detected by chemiluminescence method. The levels of serum progesterone and β-HCG in the two groups were compared between 4 and 6 weeks Serum progesterone and β-HCG levels change. Results The level of β-HCG in the fourth week of ectopic pregnancy group was not significantly different from that of the normal pregnancy group (P> 0.05). The level of progesterone in the ectopic pregnancy group was significantly lower than that of the normal pregnancy group (P <0.05) (P <0.05). The coincidence rate of progesterone and β-HCG was significantly higher than that of β-HCG alone (P <0.05). Conclusion The combination of serum progesterone and β-HCG can early diagnose ectopic pregnancy quickly and reduce the missed diagnosis and misdiagnosis, which is worth popularizing and applying.