The rapid development of biotechnology has provided a greater understanding of the biological functions of major candidate genes that have important functions regarding economic traits,and new materials for livestock breeding have been obtained through gene editing (GE) and embryo manipulation with the purpose of improving quality and output and reducing the costs and risk of disease.Public concs,particularly over safety risks and production performance,must be addressed.Evaluation is the most important component of the regulation of gene-edited livestock and is a crucial guarantee of public safety before the marketing of geneedited animal products.Here,the system of evaluation of gene-edited livestock is discussed in terms of public safety and production performance.The search for safe and ethical applications in the GE of livestock,a case-by-case evaluation strategy,and classification and simplification are used in order to promote a more efficient,objective,comprehensive and operable evaluation system.