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Ultracaine(articain)局部麻醉作用很强,而全身毒性作用很低,因其吸收后和血浆蛋白的结合率高达95％,绝大部分在血循环中失去活性。为提高麻醉效果,可以使用4％溶液,很适用于小儿、孕妇、老年人以及心血管病患者,因其代谢物很快经肾排出,比利多卡因快4倍,短时内重复注射是安全的,没有发生蓄积作用的危险。浸润麻醉效果好,有些病例可替代传导麻醉,从而减少传导麻醉的并发症。注射时可以加或不加血管收缩剂(肾上腺素),因而减少血管收缩剂的不良反应。
Ultracaine (articain) has a strong local anesthetic effect and a very low systemic toxicity due to its uptake of up to 95% of plasma protein after absorption, most of which is lost in the bloodstream. To improve the anesthetic effect, you can use 4% solution, is very suitable for children, pregnant women, the elderly and cardiovascular patients, because of its metabolites quickly by renal excretion, lidocaine 4 times faster, short-term repeated injection is Safe, there is no danger of accumulation. Infiltration anesthesia effect is good, some cases can replace conduction anesthesia, thereby reducing the complications of conduction anesthesia. Injection with or without vasoconstrictor (epinephrine), thus reducing the adverse reactions of vasoconstrictors.