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目的观察乌司他丁对慢性阻塞性肺疾病急性期患者血清肿瘤坏死因子-α、C反应蛋白及肺功能的影响。方法慢性阻塞性肺疾病急性期患者80例随机分为观察组与对照组各40例,对照组给予常规治疗,观察组在对照组治疗基础上给予乌司他丁10万u/次+生理盐水100mL,静脉滴注,2次/d,2组疗程均为7d。比较2组治疗前、后血清肿瘤坏死因子-α、C反应蛋白及肺功能变化。结果 2组治疗后血清肿瘤坏死因子-α、C反应蛋白水平均较治疗前降低(P<0.05),治疗后1s用力呼气容积、用力肺活量及二者比值、氧合指数,pa(CO2)均较治疗前改善(P<0.05);观察组治疗后血清肿瘤坏死因子-α、C反应蛋白、1s用力呼气容积、用力肺活量、1s用力呼气容积/用力肺活量与对照组比较差异有统计学意义(P<0.05)。结论乌司他丁可减轻慢性阻塞性肺疾病急性期患者气道炎性反应,改善肺功能。
Objective To investigate the effect of ulinastatin on serum tumor necrosis factor-α, C-reactive protein and pulmonary function in patients with chronic obstructive pulmonary disease. Methods Eighty patients with acute obstructive pulmonary disease were randomly divided into observation group (40 cases) and control group (40 cases). The control group was given routine treatment. The observation group was treated with ulinastatin (100 000 u / times plus normal saline 100mL, intravenous infusion, 2 times / d, 2 groups of treatment were 7d. The changes of serum tumor necrosis factor-α, C-reactive protein and lung function in two groups before and after treatment were compared. Results Serum levels of tumor necrosis factor-α and C-reactive protein in both groups were significantly lower than those before treatment (P <0.05). After 1-second treatment, forced expiratory volume, forced vital capacity and the ratio of the two, oxygenation index, (P <0.05). The levels of serum tumor necrosis factor-α, C-reactive protein, forced expiratory volume in 1s, forced vital capacity, forced expiratory volume in 1s and forced vital capacity in observation group after treatment were significantly lower than those in control group Significance (P <0.05). Conclusion Ulinastatin can reduce airway inflammatory response in patients with acute obstructive pulmonary disease and improve pulmonary function.