The mutual-interference phenomenon a-mong multiple applications delivered as services through Cloud Services Delivery Network (CSDN) influences their QoS seriously. In order to deploy multiple applications dependably and efficiently, we propose the Multiple Applications Co-Exist (MACE) method. MACE classifies multiple applications into different types and deploys them using isolation to some extent. Meanwhile, resource static allocation, dynamic supplement and resource reserved mecha-nism to minimize mutual-interference and maximize resource utilization are designed. After MACE is ap-plied to a real large-scale CSDN and evaluated through 6-month measurement, we find that the CSDN load is more balanced, the bandwidth utiliza-tion increases by about 20%, the multiple applications potential statistical multiplexing ratio decreases from 12% to 5%, and the number of complaint events affecting the dependability of CS-DN services caused by multiple applications mutu-al-interference has dropped to 0. Obviously, MACE offers a tradeoff and improvement for the depend-ability and efficiency goals of CSDN.