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Recently it has been shown that induction of tissue factor (TF) by TNF in vitro is dependent on a concerted action of NFkB and AP-1. However it remains unknown, if TF can mediate intravascular fibrin formation and if NFkB and AP-1 are involved in intravascular fibrin formation in vivo. When mice with Meth-A sarcomas were injected with TNF; TF was expressed by vascular endothelium of the tumor,
Recently it has been shown that induction of tissue factor (TF) by TNF in vitro is dependent on a concerted action of NFkB and AP-1. However it remains unknown, if TF can mediate intravascular fibrin formation and if NFkB and AP-1 are When in intravascular fibrin formation in vivo. When mice with Meth-A sarcomas were injected with TNF; TF was expressed by vascular endothelium of the tumor,