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目的回顾性调查分析乙肝肝衰竭患者临床输注新鲜冰冻血浆(fresh frozen plasma,FFP)的资料,了解输注FFP对于改善预后的疗效。方法查阅2009-12/2013-07在四川省人民医院住院的88例乙肝肝衰竭患者,观察时间为4周,根据观察期间是否输注FFP分为2组,对照组31例未输注FFP,治疗组57例输注FFP,比较2组患者住院4周后和入院时的终末期肝病模型(Model for end-stage liver disease,MELD)评分,分析是否输注FFP和血浆用量对预后的影响,综合评估患者临床转归。结果对照组MELD评分差值1.74±12.12,治疗组MELD评分差值-0.46±8.03,2组比较差异无统计学意义(t’=-0.91,P>0.05)。治疗组的血浆用量和MELD评分差值使用直线相关分析,直线相关系数r=0.11 P>0.05,无直线相关关系。结论输注FFP不能改善乙肝肝衰竭患者的预后,不推荐预防性应用。
Objective To retrospectively investigate the clinical data of fresh frozen plasma (FFP) in patients with hepatitis B liver failure and evaluate the effect of FFP infusion on prognosis. Methods Totally 88 patients with hepatitis B liver failure hospitalized in Sichuan Provincial People’s Hospital from December 2009 to July 2013 were enrolled in the study. The observation time was 4 weeks. FFP was divided into 2 groups according to the observation period, 31 cases in the control group without FFP infusion, Fifty-seven patients in the treatment group were infused with FFP to compare the two groups of patients after hospitalization for 4 weeks and admission for the model of end-stage liver disease (MELD) score, analysis of whether the infusion of FFP and plasma dosage on the prognosis, Comprehensive evaluation of the clinical outcome of patients. Results The MELD score of the control group was 1.74 ± 12.12, while the MELD score of the treatment group was -0.46 ± 8.03. There was no significant difference between the two groups (t ’= - 0.91, P> 0.05). There was no linear correlation between the plasma level of the treatment group and the MELD score using linear correlation analysis, the linear correlation coefficient r = 0.11 P> 0.05. Conclusion Infusion of FFP can not improve the prognosis of patients with hepatitis B failure, prophylactic use is not recommended.