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目的了解乙肝疫苗两种不同接种剂量对7~12岁学龄儿童的免疫效果。方法选择两所小学作为调查点,从乙肝5项指标全阴的7~12岁学生中各随机抽160人,再随机分为10ug和5ug两个剂量组,于接种第三针1个月后采静脉血,用电化学发光法(ECLA)检测抗-HBs滴度水平。结果 10ug、5ug两个剂量组学生抗-HBs阳性率分别为96.25%(95%CI:96.25%~100.00%)、85.62%%(95%CI:83.76%~95.26%),差异有统计学意义(P<0.05),不同学校、性别学生阳性率差异均无统计学意义。结论接种10ug乙肝疫苗对7~12岁学龄儿童免疫效果优于接种5ug,建议加大该年龄组乙肝疫苗接种剂量,以提高保护率,降低感染乙肝风险。
Objective To understand the immune effects of two different doses of hepatitis B vaccine on school-age children aged 7-12 years. Methods Two primary schools were selected as the investigation points. 160 randomly selected 7 to 12-year-old students with 5 indicators of hepatitis B were randomly divided into two groups of 10ug and 5ug. One month after the third inoculation, Venous blood was collected and the level of anti-HBs titer was detected by electrochemiluminescence (ECLA). Results The positive rates of anti-HBs in two dose groups of 10ug and 5ug were 96.25% (95% CI 96.25% -100.00%) and 85.62% (95% CI 83.76% -95.26%, respectively), the difference was statistically significant (P <0.05). There was no significant difference in the positive rates among different schools and sexes. Conclusion The vaccination effect of vaccinated 10ug hepatitis B vaccine is better than 5ug vaccination vaccination of 7 ~ 12-year-old school-age children. It is suggested to increase the vaccination dose of hepatitis B in this age group in order to increase the protection rate and reduce the risk of hepatitis B infection.