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目的 观察围绝经期妇女不同时期骨密度的变化情况,为临床防治围绝经期骨质疏松症提供理论指导.方法选取153例围绝经期妇女为研究对象,按照绝经时间分为3组,绝经前期51例(A组),平均年龄(42.56±4.26)岁;绝经期48例(B组),绝经时间1年,平均年龄(52.23±4.33)岁,3组均采用双能X线骨密度仪测定受试者腰正位(L2～4)及左髋部(股骨颈)、大转子、华氏三角区部位的骨密度(BMD)情况;同时检测其血清雌二醇(E2)水平、骨代谢指标[包括I型羧基末端肽(CTX)、氨基酸中段骨钙素(NMID)、I型前胶原氨基端前肽(PINP)]的情况.结果(1)C组较A组和B组各部位BMD显著降低(P<0.05);B组较A组腰L2～4、股骨颈部位的BMD显著降低(P0.05).(2)各组雌激素水平、骨代谢指标的情况表明,C组较A组和B组血清E2值呈显著下降趋势,NMID、CTX、PINP水平呈显著升高趋势;B组较A组血清E2值明显下降,NMID、CTX、PINP水平明显升高,差异均有统计学意义(P<0.05).结论围绝经期妇女随绝经年龄增加,骨质疏松症明显上升,因此预防工作应尽早开始.“,”Objective To observe the change of bone density in peri-menopausal women in different periods and provide theoretical guidance for clinical prevention and treatment of postmenopausal osteoporosis. Methods Fifty-one menopausal women were divided into three groups according to menopause, 51 patients(Group A) with an average age of (42. 56 + 4. 26);48 menopause(Group B), menopause time1 year, the average age of (52. 23 ± 4. 33). The bone mineral density (BMD)of the lumbar anteroposterior(2～4)and the left hip(femoral neck), major rotator and Fahrenheit triangle were measured by dual energy X-ray absorptiometry; While detecting the serum levels of estradiol(E2) and bone metabolic indices including type Ⅰ carboxy terminal peptide(CTX) and amino acid in the middle before osteocalcin(NMID), type Ⅰ collagen amino terminal propeptide(PINP). Results (1) Compared with group A and group B, BMD in group C decreased significantly (P<0. 05);the BMD of L2～4 and femoral neck in group B was significantly lower than that in group A (P0. 05). (2)The estrogen levels, bone metabolism index in groups showed that serum E2 values were significantly lower and NMID, CTX, PINP levels was significantly increased in group C than that of group A and group B, (P<0. 05); the serum E2 values were significantly lower and the levels of NMID, CTX and PINP were significantly higher in group B than that of group A, and the differences were statistically significant (P<0. 05). Conclusion With menopause age increased, osteoporosis increased significantly for peri-menopausal women, so the prevention work should begin as soon as possible.