J.Am.Chem.Soc.2015,137,9820~9823有机叠氮类化合物不仅在化学生物学和药物化学中有着广泛的用途,也是重要的有机及材料合成中间体.因此,有机叠氮化合物的合成受到化学家的广泛关注.以廉价易得的羧酸为原料,通过自由基方法脱羧叠氮化,是合成叠氮化合物的重要方法.但是,以往的方法均需要先将羧酸转化为巴顿酯或其类似物,再与叠氮试剂反应,因而效率低下.中国科学院上海有机化学研究所李超忠课题组以硝酸银为催化剂,过硫酸钾为氧化剂,在水相中将烷基羧酸 J.Am.Chem.Soc.2015,137,9820 ~ 9823 Organic azides not only have a wide range of uses in chemical biology and medicinal chemistry, but also are important organic and material synthesis intermediates.Therefore, organic azides Has attracted wide attention from chemists, and it is an important method to synthesize azide by using free-available carboxylic acid as a raw material to decarboxylation and azidation by a radical method. However, in the prior art, carboxylic acid was first converted into Barton ester or its analogues, and then react with the azide reagent, and thus inefficient.Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Li Chaozhong task group to silver nitrate as a catalyst, potassium persulfate as oxidant in the aqueous phase alkyl carboxylic acid