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目的:观察血管紧张素Ⅰ转化酶(ACE)基因16内含子插入/缺失(I/D)多态性与海南黎族高血压人群血脂的关系。方法:根据血压的的正常与否,将研究对象分为对照组与高血压组;采血检测血脂水平,检测血中ACE基因16内含子I/D多态标记,分析各基因型与血脂关系。结果:2组之间DD、DI、II基因型频率及D、I等位基因频率均差异无统计学意义。高血压组各基因型之间血脂水平差异亦无统计学意义。结论:ACE基因I/D多态性与黎族高血压无显著关联;与黎族高血压患者血脂水平无明显相关。
Objective: To investigate the relationship between the intron insertion / deletion (I / D) polymorphism of angiotensin Ⅰ converting enzyme (ACE) gene 16 and the blood lipids in Hainan Li population. Methods: According to whether the blood pressure was normal or not, the subjects were divided into the control group and the hypertension group. Blood samples were collected to detect the level of serum lipids and ACE gene 16 intron I / D polymorphism markers were detected. . Results: There was no significant difference in the frequencies of DD, DI, II genotypes and D, I allele frequencies between the two groups. There was no significant difference in blood lipid levels between genotypes of hypertension group. Conclusion: The ACE gene I / D polymorphism is not significantly associated with Li hypertension, and there is no significant correlation between the I / D polymorphism of ACE gene and the blood lipid level in Li hypertension patients.