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采用电化学方法研究了阳离子表面活性剂对双氢青蒿素(DHA)在银电极表面伏安行为的影响,并探讨了其电极界面的电化学机理。随着阳离子表面活性剂十六烷基三甲基溴化铵(CTMAB)的加入,DHA的还原峰电位发生明显的变化。当CTMAB的浓度为1.0×10-5mol/L时,DHA的峰电位正移了102 mV,活化能降低,DHA的过氧键更容易断裂。当CTMAB的浓度继续增大至7.0×10-4mol/L,DHA的峰电位负移了108 mV,活化能增大,DHA的过氧键更稳定。同时,还研究了酸度、温度和不同结构的阳离子表面活性剂对DHA伏安行为的影响,并提出其作用机制,从而建立一种提高DHA电化学检测分辨率的新方法。
The effect of cationic surfactants on the voltammetric behavior of dihydroartemisinin (DHA) on silver electrode was studied by electrochemical method and the electrochemical mechanism of the electrode interface was also discussed. With the addition of cetyltrimethylammonium bromide (CTMAB), the reduction peak potential of DHA changed obviously. When the concentration of CTMAB was 1.0 × 10-5mol / L, the peak potential of DHA was shifted 102 mV, the activation energy decreased, and the DHA peroxy bond was more easily broken. When the concentration of CTMAB continued to increase to 7.0 × 10-4mol / L, the peak potential of DHA shifted negatively by 108 mV, the activation energy increased, and DHA’s peroxide bond was more stable. At the same time, the influence of acidity, temperature and cationic surfactants with different structures on the voltammetric behavior of DHA was also studied. The mechanism of action was also proposed, and a new method to improve the resolution of DHA electrochemical detection was established.