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慢性肾功能衰竭(CRF)伴随1,25(OH)_2D_3血浆浓度降低,并趋于发生低血钙和继发性甲旁亢,常用1,25(OH)_2D_3治疗。然而,有认为治疗后血肌酐(Scr)增加致使肾功能恶化。本研究旨在用更特异的方法对1,25(OH)_2D_3治疗时的肾小球滤过率(GFR)进行评价。病人和方法 CRF10例,男5,女5,年龄32～68(平均52.7±10.4)岁;CRF 继发于肾小球炎5例,肾盂肾炎3例,多囊肾2例。
Chronic renal failure (CRF) accompanied by 1,25 (OH) _2D_3 plasma concentrations decreased, and tends to hypocalcemia and secondary hyperparathyroidism, commonly used 1,25 (OH) _2D_3 treatment. However, it is thought that an increase in serum creatinine (Scr) after treatment leads to a deterioration in renal function. This study aimed to evaluate the glomerular filtration rate (GFR) of 1,25 (OH) _2D_3 treatment with a more specific method. Patients and methods CRF10 cases, male 5, female 5, age 32 to 68 (average 52.7 ± 10.4) years of age; CRF secondary to glomerular inflammation in 5 cases, pyelonephritis in 3 cases, 2 cases of polycystic kidney disease.