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为提高唐氏综合征的检出率,用三联试验(即孕母血清AFP、E_3和hCG)对不同年龄孕妇进行唐氏综合征筛查。 用美国1974～1997年期间13～49岁各年龄女性所分娩活产儿的出生率统计结果,用敏感度,假阳性率,阳性预测值,似然比(敏感度/假阳性率)为指标评价了各种中孕期唐氏综合征筛查策略的实际效果。方案1,所有分娩时在35～49岁妇女为高危。方案2,假定所有妇女接受三联筛查并以1:270为截断值(cutoff)以检出高危者。方案3,认为所有35
To improve the detection rate of Down Syndrome, Down’s Syndrome Screening Screening Pregnant Women of Different Ages with Triple Experiments (ie, Maternal Serum AFP, E_3 and hCG). According to the statistics of the birth rates of live births of women of all ages from 13 to 49 in the United States from 1974 to 1997, the sensitivity, false positive rate, positive predictive value and likelihood ratio (sensitivity / false positive rate) were used as indexes Practical results of various screening strategies for Down’s syndrome in mid-pregnancy. Option 1, All women aged 35-49 years at delivery are at high risk. Option 2, assuming all women undergo triple-screen screening and cut off at a 1: 270 cut-off to detect those at risk. Option 3, think of all 35