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本文概述了棉酚与钾代谢关系的文献,也报导了这方面的以及涉及前列腺素问题的一些新资料。从多数动物实验和临床药理研究来判断,棉酚与钾和前列腺素代谢的关系大致可归纳为:1.棉酚可以影响钾代谢。在人类,棉酚可通过肾失钾而引起体钾丧失和低血钾症;在大鼠,棉酚对钾代谢的影响主要表现在细胞内钾离子浓度下降。棉酚影响钾代谢的可能机理为干扰Na-K-LATP 酶活性及促进前列腺素的生物合成。初步的实验结果提示,前列腺素也可能参与棉酚的抑制生精机制。2.棉酚对钾代谢的影响是有条件的,在机体摄入钾量低下时,此影响较为明显,摄入钾量充分时则不显著。3.预防性使用钾盐,即补充钾摄入量的不足,可防止棉酚所引起的低血钾性麻痹。但作者认为,此问题的最终解决,将求助于增加食物钾量,甚或改变棉酚结构。
This article provides an overview of the literature on the relationship between gossypol and potassium metabolism, as well as some new sources of data on this and prostaglandin issues. Judging from most animal experiments and clinical pharmacological studies, the relationship between gossypol and potassium and prostaglandin metabolism can be summarized as follows: 1. Gossypol can affect potassium metabolism. In humans, gossypol causes loss of body potassium and hypokalemia through loss of potassium from the kidney; in rats, the effect of gossypol on potassium metabolism is mainly manifested by a decrease in intracellular potassium concentration. Possible mechanisms by which gossypol affects potassium metabolism are interference with Na-K-LATPase activity and promotion of prostaglandin biosynthesis. Preliminary experimental results suggest that prostaglandins may also participate in the mechanism of inhibition of spermatogenesis gossypol. 2. Gossypol on potassium metabolism is conditional, when the body intake of low potassium, this effect is more obvious, when the intake of potassium is sufficient, it is not significant. 3 prophylactic use of potassium, that is, inadequate potassium intake to prevent gossypol-induced hypokalemic paralysis. However, the authors believe that the ultimate solution to this problem will be to resort to increasing the amount of potassium in food or even changing the gossypol structure.