【摘 要】
：
An improved and scalable process for substituted 3,8-diazabicyclo [3.2.1]octane was developed. N-Benzyl-2,5-dicarbethoxy-pyrrolidine 2 was reduced to N-benzyl-2
【机 构】
：
College of Chemical Engineering
论文部分内容阅读
An improved and scalable process for substituted 3,8-diazabicyclo [3.2.1]octane was developed. N-Benzyl-2,5-dicarbethoxy-pyrrolidine 2 was reduced to N-benzyl-2,5-dihydroxymethylpyrrolidine 9 and subsequently debenzylated to afford N-Boc-2,5-dihydroxymethylpyrrolidine 10. After mesylation of the diol 10 and cyclization with benzylamine, a diversity of scaffold, 3,8-diazabicyclo [3.2.1 ]octane analogue 12 was obtained in a total yield of 42% in five steps.
其他文献
本文试图从会话结构对对外汉语初级口语教材的趣味性进行分析,以探寻可供借鉴的汉语教材编写特点,为对外汉语教材的发展提供一些参考。
This article attempts to analyze t
“A什么(A)”和“A什么B”句式是现代汉语口语中常见的两类表示消极意义的结构。进入两类句式的语法单位各不相同,但两类句式实际上具有相同的结构形式。两类句式在语义上都
小说中的叙述者指讲述故事的人,与叙述声音密切相关。评论功能是叙述者在小说中的功能之一,分为公开评论和隐蔽评论。本文通过对比分析《尤利西斯》的两个汉译本,借以说明译
对江苏省淮安市336例高中学生(男125例,女211例)抽样调查的汉族7项不对称行为特征(包括扣手、利手、叠臂、叠腿、利足、起步类型和优势眼)资料进行研究.研究结果显示:(1)除叠
性别差异是言语交际中普遍存在的社会现象.从语用学的视角出发,以美剧《绝望主妇》中的异性会话作为语料,从合作原则、礼貌原则和面子论的遵守和违反三方面对英语异性会话中
Ground stress is the fundamental cause of deformation and failure during underground structural engineering.Field stress measurements in the main coal bed in th
Based on a high resolution and high signal-to-noise ratio (S/N) spectral analysis of 90 solar-type stars, we have established several new metaUicity calibration
Various aromatic α-keto esters were rapidly and selectively reduced to aromatic α-hydroxy esters by commercially available zinc dust and ammonium formate in t
The authors investigate the influence of a harmonic potential and random perturbations on the nonlinear Schr(o)dinger equations.The local and global well-posedn
To apply the measurements of model experiment in water tunnel to the actual sailing condition,it is necessary to know accurately the strut effect and its rule.I