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目的:探讨新生儿窒息亚低温治疗后脑干听觉诱发电位变化。方法:将符合亚低温入选条件72例窒息新生儿,随机分成亚低温组36例、常规治疗组36例,同期正常产足月儿32例为对照组,亚低温组入院后即行亚低温联合三支持三对症治疗,常规治疗组给予三支持三对症治疗,分别于治疗后(日龄6~7天)及1月(4~5周)行脑干听觉诱发电位检查。结果:亚低温治疗可降低脑干听觉诱发电位检查中Ⅰ、Ⅲ、Ⅴ波的平均潜伏期、缩短峰间期进行比较,结果有统计学差异(P<0.05)。结论:对于符合条件的患儿,尽早使用亚低温治疗并行脑干听觉诱发电位检查,提早检出窒息新生儿有无脑功能损伤和听损伤。
Objective: To investigate the changes of brainstem auditory evoked potentials after neonatal asphyxia and mild hypothermia. Methods: Seventy-two neonates with asphyxia eligible for mild hypothermia were randomly divided into mild hypothermia group (n = 36) and routine treatment group (n = 36). In the same period, 32 normal full-term infants were used as control group. Support three symptomatic treatment, conventional treatment group were given three support symptomatic treatment, respectively, after treatment (day 6 to 7 days) and January (4 to 5 weeks) brainstem auditory evoked potentials. Results: Mild hypothermia treatment can reduce the auditory evoked potential of brainstem auditory evoked potential of Ⅰ, Ⅲ, Ⅴ waves, shortening the interphase comparison, the results were statistically significant (P <0.05). Conclusion: For eligible children, early use of mild hypothermia in the treatment of brainstem auditory evoked potentials, early detection of asphyxia in neonates with or without brain injury and hearing impairment.