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一种制备含2-羟乙基砜基苯胺衍生物的方法,属于精细化工领域。其特征是以水、甲醇、乙醇、正丙醇、异丙醇、正丁醇、异丁醇、二氧六环、四氢呋喃、二甲基甲酰胺或它们的混合物为溶剂,将2-羟乙基砜基硝基苯衍生物加入溶剂中,搅拌升温至40-100℃,待还原物全部或部分溶解,加入催化剂,滴加水合肼;反应0.2-12小时,薄层色谱检查反应完毕后,趁热过滤除去催化剂。
A method for preparing 2-hydroxyethyl sulfone-based aniline derivatives belongs to the fine chemical field. Which is characterized in that 2-hydroxyethyl ketone is used as a solvent in water, methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, dioxane, tetrahydrofuran, dimethylformamide or a mixture thereof Sulfonyl nitrobenzene derivative was added to the solvent, stirred and heated to 40-100 ° C, until all or part of the reduction of dissolved dissolved, the catalyst was added dropwise hydrazine hydrate; reaction 0.2-12 hours, after the TLC check the reaction is complete, Remove the catalyst by hot filtration.