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目的探讨152例0型血孕妇血型抗体效价与新生儿溶血病(HDN)发生的关系。方法根据O型孕妇妊娠16～32w测定的IgG抗A(B)效价,将其分成4组(≤1∶32,1∶64,1∶128,≥1∶256),比较分析各组新生儿溶血病的发生率。对部分效价过高者采取中药治疗的处理,比较分析其疗效。结果新生儿ABO溶血的发生率与母亲抗体效价相关,效价越高,新生儿溶血病发生率越高,差异有显著性(P<0.05)。孕妇IgG抗A(B)效价过高采取中药治疗一定程度上降低了新生儿溶血病发生率,但差异无显著性(P>0.05)。结论 O型孕妇血清IgG抗体与新生儿ABO溶血病存在相关性,孕期检测抗体效价有必要。
Objective To investigate the relationship between blood group antibody titers and hemolytic disease (HDN) in 152 cases of type 0 blood pregnant women. Methods According to the IgG anti-A (B) titers of O-pregnant women measured at 16 to 32 weeks of gestation, they were divided into 4 groups (≤1:32, 1:64, 1:128, ≥1:256) Hemolytic disease incidence. To some of the overvalued people to take traditional Chinese medicine treatment, comparative analysis of its efficacy. Results The incidence of ABO hemolysis in neonates was correlated with maternal antibody titer. The higher the titer was, the higher the incidence of hemolytic disease in neonates was (P <0.05). Pregnant women with high anti-A (B) titer to take traditional Chinese medicine treatment to a certain extent, reduce the incidence of hemolytic disease in newborns, but no significant difference (P> 0.05). Conclusion O-type pregnant women serum IgG antibody and neonatal ABO hemolytic disease is related to the detection of antibody titers during pregnancy is necessary.