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目的探讨维持性血液透析患者血尿酸水平与高血压的关系,血尿酸对高血压的影响机制以及临床意义。方法选择2008年01月至2011年01月我院接收的60例维持性血液透析患者,要求透析3个月以上,每周透析2～3次,使用碳酸氢钠透析液透析,分为血尿酸升高组30例和血尿酸正常组30例(以血尿酸正常参考值440umol/L为分界点)。指标通过全自动生化分析仪测定;血压采用间接测量方法。高血压合并高尿酸患者,别嘌呤醇100mg口服,1次/d,4周后观察血压和血尿酸。结果在尿酸正常组高血压发生率为26.67%,在血尿酸升高组高血压的发生率为63.33%,两组比较差异有统计学意义(P<0.05)。与尿酸正常组相比,尿酸升高组的UA值也具有统计学意义。结论血尿酸与透析患者的高血压有着密切关联,积极控制血尿酸水平可能是防治高血压的新靶点。
Objective To investigate the relationship between serum uric acid level and hypertension in maintenance hemodialysis patients, the mechanism of serum uric acid on hypertension and its clinical significance. Methods January 2008 to January 2011 received 60 cases of maintenance hemodialysis patients in our hospital, requiring dialysis for more than 3 months, dialysis 2 to 3 times per week, the use of sodium bicarbonate dialysate dialysis, divided into uric acid 30 cases of elevated group and 30 cases of normal serum uric acid group (the normal reference value of serum uric acid 440umol / L as the cut-off point). Indicators measured by automatic biochemical analyzer; blood pressure using indirect measurement methods. Hypertension patients with high uric acid, allopurinol 100mg orally, 1 / d, 4 weeks after the observation of blood pressure and serum uric acid. Results The incidence of hypertension in normal uric acid group was 26.67%, while that in hypertension group was 63.33%. There was significant difference between the two groups (P <0.05). Compared with the normal uric acid group, UA in the uric acid increased group was also statistically significant. Conclusion Serum uric acid and dialysis patients with hypertension are closely related to the positive control of serum uric acid levels may be a new target of prevention and treatment of hypertension.