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目的探讨绒毛细胞染色体异常与孕早期自然流产间的临床关系。方法对214例妊娠早期自然流产患者绒毛细胞进行培养,染色体制备及核型分析。结果进行绒毛细胞染色体培养214例,培养成功201例,总体成功率达93.9%,可用于染色体核型分析报告198例,分析成功率为92.5%。共分析绒毛标本198例,其中检出正常核型101例,占51.0%(101/198);异常核型97例,占49.0%(97/198)。异常核型中以数目异常为主,其中常染色体三体最多见,61例(63%);三倍体13例(13%);性染色体异常9例(9%);结构异常8例(8%)。结论胚胎染色体异常时导致妊娠早期自然流产的重要因素之一,临床上开展流产绒毛染色体检查有利于判断本次流产原因,合理指导下次妊娠。
Objective To investigate the clinical relationship between chorionic villus chromosome abnormalities and spontaneous abortion in early pregnancy. Methods 214 cases of spontaneous abortion in early pregnancy villi cells were cultured, chromosome preparation and karyotype analysis. Results 214 cases of chorionic villus chromosome culture, 201 cases of successful culture, the overall success rate of 93.9%, 198 cases can be used for chromosome karyotype analysis, analysis of success rate was 92.5%. A total of 198 villus samples were analyzed. Among them, 101 cases were normal karyotypes, accounting for 51.0% (101/198); 97 cases were abnormal karyotypes, accounting for 49.0% (97/198). Abnormal karyotype in the number of anomalies, including autosomal trisomy most common, 61 cases (63%); triploid in 13 cases (13%); 9 cases of chromosomal abnormalities (9%); structural abnormalities in 8 cases 8%). Conclusion Abnormal fetal chromosome abnormalities lead to spontaneous abortion in early pregnancy one of the important factors in the clinical diagnosis of abortion chorion is conducive to determine the causes of this miscarriage, reasonable guidance of the next pregnancy.