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目的和方法：选用热凝造成大脑中动脉阻断（ＭＣＡＯ）而致实验性大鼠脑局灶性缺血模型，观察汉防己甲素（ｔｅｔｒａｎｄｒｉｎｅ，ＴＥＴ）对大鼠脑局灶性缺血的防治作用。结果：ＴＥＴ组用药七天，脑梗塞范围明显小于缺血组，缺血区脑组织Ｃａ２＋、Ｎａ＋、过氧化脂质（ＬＰＯ）、血浆血栓素Ｂ２（ＴＸＢ２）明显低于缺血组，而超氧化物歧化酶（ＳＯＤ）明显高于缺血组，６－酮－前列腺素Ｆ１α（６－ｋｅｔｏＰＧＦ１α）无显著改变，ＴＸＢ２／６－酮（Ｔ／Ｋ）比值明显低于缺血组。结论：ＴＥＴ具有对大鼠ＭＣＡＯ局灶性脑缺血有效的防治作用，其机制可能与减少脑组织缺血区Ｃａ２＋、Ｎａ＋、ＬＰＯ含量，降低ＴＸＢ２，使Ｔ／Ｋ比值趋于正常有关。
Objective and Methods: Experimental focal cerebral ischemia model was induced by middle cerebral artery occlusion (MCAO) caused by thermal coagulation. The effects of tetrandrine (TET) on focal cerebral ischemia in rats Prevention and treatment. Results: In the TET group, the infarct volume in the TET group was significantly less than that in the ischemia group. The levels of Ca2 +, Na +, LPO and TXB2 in the ischemic area were significantly lower than those in the ischemic group, The content of superoxide dismutase (SOD) was significantly higher than that of the ischemic group. There was no significant change of 6-keto-PGF1α and TXB2 / 6-keto (T / K) ratio was significantly lower than that of the ischemic group. CONCLUSION: TET can effectively prevent and cure focal cerebral ischemia in rats. The mechanism may be related to the reduction of Ca2 +, Na +, LPO content and TXB2 in the ischemic area of brain tissue, and the T / K ratio tends to be normal.