目的:比较分析三种不同联合用药方案治疗消化性溃疡的临床疗效及不良反应发生率。方法:选取近两年在我院接受治疗的182例消化性溃疡患者作为研究对象,随机分为三组:A组60例、B组62例和C组60例,分别接受三种不同的方案治疗,比较分析三组患者的疗效、不良反应及复发率等。结果:三组临床总有效率分别为81.7%、93.5%和78.3%,B显著高于A组和C组,经卡方检验,差异有统计学意义,P<0.05;三组HP根除率分别为63.3%、70.9%和55.0%,B显著高于C组,经卡方检验,差异有统计学意义,P<0.05;三组临床症状平均消失时间分别为(2.2±2.9)周、(1.4±2.8)周和(2.1±2.6)周,B显著低于A、C两组,经方差分析,差异有统计学意义,P<0.05;三组不良反应发生率分别为10.0%、4.8%和13.3%,B显著低于A、C两组组,经卡方检验,差异有统计学意义,P<0.05。结论:胃可安胶囊、埃索美拉唑、克拉霉素片和阿莫西林胶囊联合用药治疗消化性溃疡临床见效快且有效率高,不良反应发生率低。 Objective: To compare and analyze the clinical efficacy and incidence of adverse reactions of three different combination regimens in the treatment of peptic ulcer. Methods: A total of 182 patients with peptic ulcer treated in our hospital for the past two years were randomly divided into three groups: A group of 60 patients, B group of 62 patients and C group of 60 patients receiving three different protocols Treatment, comparative analysis of three groups of patients efficacy, adverse reactions and recurrence rate. Results: The total clinical effective rates of the three groups were 81.7%, 93.5% and 78.3%, respectively, and B was significantly higher than those of the A and C groups. The chi square test showed that the difference was statistically significant (P <0.05) (63.3%, 70.9% and 55.0%, respectively), and B was significantly higher than that in group C. The chi square test showed that the difference was statistically significant (P <0.05) ± 2.8) weeks and (2.1 ± 2.6) weeks, B was significantly lower than those in A and C groups, and the difference was statistically significant (P <0.05) by analysis of variance. The incidences of adverse reactions in the three groups were 10.0% and 4.8% 13.3%, B was significantly lower than A, C two groups, the chi-square test, the difference was statistically significant, P <0.05. Conclusion: The combination of Weikean capsules, esomeprazole, clarithromycin tablets and amoxicillin capsules in the treatment of peptic ulcer has the advantages of quick and effective clinical treatment and low incidence of adverse reactions.