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用喂饲含高氟水的方法制造了大鼠慢性氟中毒模型。动物在自由清醒状态下经留置心房导管注射药物及采血。观察了喹哌嗪、吗啡和 TRH 诱发的催乳素(PRL)分泌的变化。结果表明慢性氟中毒大鼠喹哌嗪、吗啡和 TRH 诱发的 PRL 分泌降低。提示氟中毒时 PRL 分泌的下丘脑—垂体调节发生紊乱。
Chronic fluorosis model of rats was made by feeding high fluorine water. Animals were left awake in a free state of atrial catheter injection and blood collection. The changes of prolactin (PRL) secretion induced by quipiperazine, morphine and TRH were observed. The results show that chronic fluorosis rats Quipirazine, morphine and TRH induced PRL secretion decreased. Hypothalamus-pituitary regulation prompting the secretion of PRL during fluorosis is disturbed.