[目的]寻找高效、低毒、低残留的环境友好型杀虫剂。[方法]利用“中间体衍生化”方法,设计、合成了11个含哌嗪的二氯丙烯醚衍生物。以对苯二酚、1,1,1,3-四氯丙烷为起始原料经5步反应生成目标化合物,其结构经1H NMR确证。[结果]初步的生物活性数据表明,化合物2、4在100 mg/L质量浓度下,对小菜蛾2龄幼虫的致死率高于90%,优于其他化合物,尤其是化合物2在6.25 mg/L质量浓度下致死率达到90%,优于对照化合物pyridalyl。 [Objective] The research aimed to find an environment-friendly pesticide with high efficiency, low toxicity and low residue. [Method] With the method of “intermediate derivatization”, 11 piperazine derivatives of dichloro propenyl ether were designed and synthesized. Hydroquinone and 1,1,1,3-tetrachloropropane were used as starting materials to prepare the target compounds in 5 steps. The structures were confirmed by 1H NMR. [Result] The preliminary biological activity data showed that the lethality of compound 2 and 4 to the 2nd instar larvae of Plutella xylostella was higher than 90% under the concentration of 100 mg / L, which was superior to other compounds especially when compound 2 was at 6.25 mg / L mass concentration of 90% lethality, better than the control compound pyridalyl.