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目的:观察并探究在治疗抗结核药导致药物性肝炎中应用复方甘草酸苷具有的临床效果。方法:将我院收治的146例抗结核药物性肝炎患者随机分为对照组与观察组,每组73例。给予对照组常规治疗,观察组则接受复方甘草酸苷治疗,并对两组临床疗效进行统计与比较。结果:经过4周的药物治疗,观察组的治疗效果明显优于对照组,数据差异显著,具备统计学意义(P<0.05)。结论:在治疗抗结核药所致的药物性肝炎中应用复方甘草酸苷,具有非常好的降酶保肝作用,不良反应少且疗效显著,值得临床大力推广与应用。
Objective: To observe and explore the clinical efficacy of compound glycyrrhizin in the treatment of drug-induced hepatitis caused by anti-TB drugs. Methods: 146 patients admitted to our hospital with anti-TB drug-induced hepatitis were randomly divided into control group and observation group, with 73 cases in each group. The control group received routine treatment, the observation group received compound glycyrrhizin treatment, and the clinical efficacy of the two groups were compared and statistically. Results: After 4 weeks of drug treatment, the observation group was significantly better than the control group, with significant difference (P <0.05). Conclusion: The compound glycyrrhizin is used in the treatment of drug-induced hepatitis caused by anti-tuberculosis drugs. It has very good effect of reducing the enzyme and protecting the liver, less adverse reactions and significant curative effect. It is worthy of clinical promotion and application.