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目的 探讨孟鲁司特钠 (顺尔宁 )和草分枝杆菌F U 3 6(乌体林斯 )联合治疗婴幼儿哮喘的疗效。方法 将 96例非急性发作期婴幼儿哮喘患儿随机分为孟鲁司特钠和草分枝杆菌F U 3 6治疗组 (Ⅰ组 ) ,孟鲁司特钠治疗组 (Ⅱ组 )和对照组。Ⅰ组给予孟鲁司特钠每晚 2 5mg口服 ,草分枝杆菌F U 3 6肌注 (总量 6支 ) ;Ⅱ组每晚口服孟鲁司特钠 2 5mg ;对照组常规止咳、平喘及必要时抗感染治疗。三组共观察 12周 ,在哮喘急性发作期均予全身糖皮质激素、β2 激动剂等强化治疗。比较各组间哮喘控制参数。结果 Ⅰ组、Ⅱ组与对照组比较 ,明显改善多项哮喘控制参数。无哮喘症状的天数 ( % )、有≥ 1次哮喘发作的病人数 ( % )、需全身糖皮质激素救急的病人数 ( % )、家长评价明显好转率 ( % )、医生评价明显好转率 ( % ) ,经统计学处理 ,有非常显著性差异 ,P <0 0 1。Ⅰ组相对于Ⅱ组 ,上述各项比值差异亦具有显著性意义。每周日间哮喘症状计分 :Ⅰ组、Ⅱ组与对照组 ,Ⅰ组与Ⅱ组相比 ,P <0 0 1。每周夜间哮喘症状计分 :Ⅰ组与对照组相比 ,P <0 0 1;Ⅱ组与对照组、Ⅰ组与Ⅱ组比较 ,P <0 0 5。结论 孟鲁司特钠和草分枝杆菌F U 3 6联合治疗婴幼儿哮喘有明显的疗效 ,对于难以掌握吸入技术的婴幼儿哮喘患儿的治疗可提供一?
Objective To investigate the efficacy of combination of montelukast sodium (SD) and Mycobacterium phlei F U 3 6 (Ursolin) in the treatment of infantile asthma. Methods 96 infants with non-acute exacerbation of asthma were randomly divided into montelukast sodium and Mycobacterium phlei FU 3 6 treatment group (group Ⅰ), montelukast sodium treatment group (group Ⅱ) and control group . Group Ⅰ was given montelukast sodium orally 25mg per night orally, Mycobacterium phlei FU 3 6 intramuscular injection (total 6); Group Ⅱ oral montelukast sodium 25mg per night; control group conventional cough and asthma Anti-infective treatment if necessary. Three groups were observed for 12 weeks, both in the acute exacerbation of asthma to systemic glucocorticoid, β2 agonists and other intensive treatment. Asthma control parameters were compared between groups. Results Compared with the control group, group Ⅰ and group Ⅱ significantly improved a number of asthma control parameters. The number of patients without asthma symptoms (%), the number of patients with one episode of asthma attack (%), the number of patients requiring systemic glucocorticoid emergency (%), the parents’ appraisal rate of obvious improvement (%), %), After statistical analysis, there is a very significant difference, P <0 01. Group Ⅰ relative to group Ⅱ, the above differences also have significant significance. Weekly asthma symptom score: Ⅰ group, Ⅱ group and control group, Ⅰ group and Ⅱ group, P <0.01. Nighttime asthma symptom scores: Ⅰ group compared with the control group, P <0.01; Ⅱ group and control group, Ⅰ group and Ⅱ group, P <0 05. Conclusion The combination of montelukast and Mycobacterium phlei F U 3 6 in the treatment of asthma in infants and young children has obvious curative effect. It can provide one kind of treatment for infants and young children with asthma which is difficult to master inhalation technique.