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目的:探讨重组人脑利钠肽(rh BNP)对急性重症心力衰竭患者预后的影响。方法:将2010年8月至2013年8月收治的急性重症心力衰竭患者237例随机分为观察组(n=120)和对照组(n=117),对照组给予异舒吉治疗,观察组给予rh BNP治疗,比较两组气促缓解时间、住院时间及治疗前后尿量、液体入量、左室射血分数(LVEF)、每搏输出量(SV)、心脏指数(CI)、左心室舒张末期内径(LVDd)、N末端B型利钠肽原(NT-pro BNP)的变化。结果:治疗后,观察组24 h尿量、LVEF明显高于对照组(P<0.05);观察组呼吸困难缓解时间、住院时间、NT-pro BNP水平、不良心血管事件发生率均明显低于对照组(P<0.05)。结论 :rh BNP能有效改善急性重症心力衰竭患者左心室功能,缩短气促缓解时间、住院时间,降低不良心血管事件发生率。
Objective: To investigate the effect of recombinant human brain natriuretic peptide (rh BNP) on the prognosis of patients with acute severe heart failure. Methods: A total of 237 patients with acute severe heart failure who were admitted from August 2010 to August 2013 were randomly divided into observation group (n = 120) and control group (n = 117), control group received Isoflurane treatment, observation group The patients were given rh BNP, the time of relief, length of hospital stay, urine output, fluid volume, left ventricular ejection fraction (LVEF), stroke volume (SV), cardiac index End-diastolic diameter (LVDd) and N-terminal pro-brain natriuretic peptide (NT-pro BNP). Results: After treatment, the urine output and LVEF in observation group were significantly higher than those in control group (P <0.05). The relief time, length of hospital stay, NT-pro BNP level and incidence of adverse cardiovascular events in observation group were significantly lower than those in control group Control group (P <0.05). CONCLUSION: rh BNP can effectively improve left ventricular function, shorten the duration of shortness of breath and promote hospital stay, and reduce the incidence of adverse cardiovascular events in patients with acute severe heart failure.