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对分离自急性期病人尿液中的１株流行性出血热病毒（ＥＨＦＶ）１１４株感梁的乳鼠脑组织进行了病理组织学和电镜观察，结果显示感染乳鼠脑组织呈病毒性脑炎样改变，以海马回和大脑皮层的病变较重，海马回神经元细胞内质网和高尔基复合体明显扩张，池内和囊泡内均有管样结构，部分神经元细胞核回铝，核膜完整结构消失。成熟的病毒颗粒呈圆形或椭圆形，直径８０～１６０ｎｍ，病毒是从高尔基囊泡膜内壁上芽生进入池内的。这些形态学和形态发生学特征符合布尼安病毒科汉坦病毒属的特征，并从超微结构上为ＥＨＦＶ直接作用的发病学说提供了证据。
The pathological and electron microscopic observations of brain tissue from 114 strains of SJT of a strain of epidemic hemorrhagic fever virus (EHFV) isolated from the urine of patients with acute phase showed that the brain tissues of infected neonatal rats were viral encephalitis Like changes in the hippocampus and cerebral cortex lesions heavier, hippocampal neurons endoplasmic reticulum and Golgi complex was significantly expanded, both inside the pool and the vesicle-like structure, some of the neurons back to the nucleus of aluminum, nuclear membrane integrity Structure disappears. Mature virus particles were round or oval, diameter 80 ~ 160nm, the virus is from the inner wall of the Golgi vesicle budding into the pool. These morphological and morphological features are consistent with the characteristics of the genus Hynobius in the Bunyavirus family and provide evidence for the pathogenesis of direct effects of EHFV on the ultrastructure.