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以４０日龄雄性Ｗｉｓｔａｒ大鼠４０只，分为对照（Ｃ），糖尿病（Ｄ），糖尿病胰岛素及时治疗（ＤＣＩＲ）和糖尿病胰岛素延迟治疗（ＤＤＩＲ）组，进行睾丸间质细胞和支持细胞功能的研究。结果表明：血清睾酮Ｄ组最低，培养间质细胞睾酮分泌量ＤＣＩＲ、ＤＤＩＲ和Ｄ组均显著低于Ｃ组（Ｐ＜０．０５及０．００１），ｃＡＭＰ分泌量ＤＤＩＲ和Ｄ组显著低于Ｃ和Ｄ分别的ＣＩＲ组（Ｐ＜０．０１）；睾丸组织雄激素结合蛋白（ＡＢＰ）水平，ＤＤＩＲ组显著高于Ｃ和Ｄ组（分别为Ｐ＜０．０５及Ｐ＜０．０１），其它组间比较差异不显著，培养支持细胞ＡＢＰ分泌量Ｄ组显著低于Ｃ和ＤＣＩＲ组（Ｐ＜０．０５），ｃＡＭＰ分泌量ＤＤＩＲ和Ｄ组显著低于Ｃ和ＤＣＩＲ组（Ｐ＜０．０１）。
Forty male Wistar rats aged 40 days were divided into control (C), diabetes (D), Diabetes mellitus (DCIR) and Diabetic Insulin Delayed Treatment (DDIR) groups. The testicular stromal cells and supporting cell function the study. The results showed that the serum testosterone group D was the lowest, and the testosterone secretion in the cultured stromal cells DCIR, DDIR and D groups were significantly lower than the C group (P <0.05 and 0.001), cAMP secretion DDIR and D group was significantly lower (P <0.01). The levels of androgen-binding protein (ABP) in testis tissue were significantly higher in DDIR group than those in C and D groups (P <0.05 and P <0.01, respectively) (P <0.05). The amount of cAMP secretion in DDIR and D groups was significantly lower than that in C and DCIR groups (P <0.05), but there was no significant difference among other groups .01).