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动物和人的几种恶性肿瘤常见北随机和特异性染色体畸变。这类肿瘤细胞的遗传性异常,即其原癌基因涉及的染色体重组,常见于未分化B细胞淋巴瘤(UBL)C-myc的典型易位(8;14)和慢性粒细胞白血病(CML)C-abl的典型易位(9;22)。6号染色体长臂部分缺失(6q~-)原报告于急性淋巴细胞白血病(ALL),其发生频率在5—25%之间,非何杰金氏淋巴瘤(NHL)为30%,急性粒细胞白血病(AML)和CML的频率则较低。C-myb原癌基因大约定位于6号染色体6 p21-24区。造血系肿瘤的发生在6 q~-畸变和C-myb基因之间可能存在内在联系。C-myb mRNA原发现于造血细胞,在
Several malignant tumors of animals and humans are common to northern random and specific chromosomal aberrations. Hereditary abnormalities in these tumor cells, known as chromosomal recombination involving proto-oncogenes, are common in typical translocations of undifferentiated B-cell lymphoma (UBL) C-myc (8; 14) and in chronic myeloid leukemia (CML) Typical translocation of C-abl (9; 22). Chromosome 6 is partially deleted (6q ~ -) originally reported in acute lymphoblastic leukemia (ALL), its frequency is between 5-25%, and non-Hodgkin’s lymphoma (NHL) is 30% Leukemia (AML) and CML are less frequent. The C-myb protooncogene is located approximately on the 6th p21-24 region on chromosome 6. The occurrence of hematopoietic tumors may be intrinsically linked between the 6 q ~ - aberrations and the C-myb gene. C-myb mRNA was originally found in hematopoietic cells