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目的:研究α-L-岩藻糖苷酶(AFU)、甲种胎儿球蛋白(AFP)、高尔基体蛋白73(GP73)和磷脂酰肌醇蛋白聚糖3(GPC3)联合检测对原发性肝癌的诊断价值。方法:选择2014年1月~2016年5月在我院进行诊治的原发性肝癌患者90例为肝癌组,同期住院诊治的肝硬化患者60例为肝硬化组,以及同期在我院体检健康者60例为对照组。比较三组的AFU、AFP、GP73和GPC3水平和阳性检出率,并观察AFU、AFP、GP73和GPC3单独检测和联合检测对原发性肝癌的诊断效率。结果:肝癌组和肝硬化组的AFU、AFP、GP73和GPC3水平均明显高于对照组(P<0.05),且肝癌组明显高于肝硬化组(P<0.05);肝癌组和肝硬化组的AFU、AFP、GP73和GPC3阳性率均明显高于对照组(P<0.05),且肝癌组明显高于肝硬化组(P<0.05);AFU、AFP、GP73和GPC3联合检测对原发性肝癌的特异性、敏感性、阳性预测值及阴性预测值均明显高于单独检测和三项指标联合检测(P<0.05)。结论:AFU、AFP、GP73和GPC3联合检测可以提高对原发性肝癌的检出率,具有较高的临床应用价值。
OBJECTIVE: To investigate the effect of combined detection of alpha-L-fucosidase (AFU), alpha fetoprotein (AFP), ghrelin 73 (GP73) and glypican 3 (GPC3) The diagnostic value. Methods: Ninety patients with primary hepatocellular carcinoma who were diagnosed and treated in our hospital from January 2014 to May 2016 were selected as the hepatocellular carcinoma group, 60 patients with cirrhosis hospitalized during the same period as the cirrhosis group and the same period in our hospital 60 cases as control group. The levels of AFU, AFP, GP73 and GPC3 in the three groups were compared and the positive detection rate was compared. The diagnostic efficiency of AFU, AFP, GP73 and GPC3 alone and in combination on the detection of primary liver cancer was also observed. Results: The levels of AFU, AFP, GP73 and GPC3 in liver cancer group and cirrhosis group were significantly higher than those in control group (P <0.05), and were significantly higher in liver cancer group than in cirrhosis group (P <0.05) The positive rates of AFU, AFP, GP73 and GPC3 were significantly higher than those of the control group (P <0.05), and were significantly higher in the hepatocellular carcinoma group than in the cirrhosis group (P <0.05) The specificity, sensitivity, positive predictive value and negative predictive value of HCC were significantly higher than those of single detection and three indicators (P <0.05). Conclusion: The combined detection of AFU, AFP, GP73 and GPC3 can improve the detection rate of primary liver cancer and has high clinical value.