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目的化、放疗同时进行治疗非小细胞肺癌，企图获得最大并用疗效。方法对86例Ⅲ期非小细胞肺癌进行同时和序贯放化疗随机分组研究，同时组：局部放疗55Gy～66Gy，常规分割；同时并用大剂量顺铂、足叶乙甙组成的EP方案2周期。序贯组：治疗顺序为放疗后行2周期化疗。结果同时组与序贯组有效率、1年生存率、3年生存率、中位生存期分别为61．5％、55．8％、20．9％、13．7月和53．5％、55．8％、23．3／、13.3月。两组无明显差别。结论放疗同时应用大剂量顺铂组成的EP方案化疗治疗Ⅲ期非小细胞肺癌与放、化疗序贯治疗相比未能提高疗效。
Objective and radiotherapy for the treatment of non-small cell lung cancer at the same time, in order to obtain maximum efficacy. Methods A total of 86 patients with stage III non-small cell lung cancer were randomly divided into two groups: simultaneous and sequential radiotherapy and chemotherapy. At the same time, the group was treated with local radiotherapy at 55 Gy to 66 Gy and conventional segmentation. Simultaneous use of high-dose cisplatin and acetylcholine EP regimen consisted of 2 cycles. . Sequential group: The treatment sequence was 2 cycles of chemotherapy after radiotherapy. Results The effective rate, one-year survival rate, three-year survival rate, and median survival time of the simultaneous and sequential groups were 61.5%, 55.8%, 20.9%, 13.7 months, and 53.5%, respectively. , 55.8%, 23.3/, and 13.3 months. There was no significant difference between the two groups. Conclusion Radiotherapy combined with EP regimen consisting of large doses of cisplatin for the treatment of stage III non-small cell lung cancer can not improve the efficacy compared with the sequential therapy of radiotherapy and chemotherapy.