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目的了解寨卡病毒病的临床特点及感染者病原学检测结果,为我国寨卡病毒病防控工作提供科学依据。方法分析2016年广东省11例病例的临床特点及11例病例和3例隐性感染者标本检测结果。结果 11例病例均发生皮疹,6例眼结膜充血,4例咽部充血,2例发热(体温>37.3℃),均无肌肉关节痛表现;9例病例以皮疹、2例以发热为首发症状。皮疹持续2-8天,中位数6天,发生部位以胸部和背部为最多,成人与儿童的皮疹形态不同。病原学检测,血清PCR阳性占45.45%(5/11),唾液阳性占90.91%(10/11),尿液阳性为100%(11/11);隐性感染者中,血清检测阳性1例,唾液阳性1例,尿液阳性3例。结论寨卡病毒病症状较轻,早期发现较困难;建议采用血液、唾液、尿液同时开展核酸检测并作为诊断依据,同时在伊蚊活跃期常态下做好蚊媒密度控制工作,降低本地传播风险。
Objective To understand the clinical features of Zika virus disease and the results of pathogen detection of infected persons and provide a scientific basis for the prevention and control of Zika virus disease in our country. Methods The clinical features of 11 cases in Guangdong Province in 2016 and the detection results of 11 cases and 3 cases of latent infection were analyzed. Results All the 11 cases had rash, 6 cases of conjunctival hyperemia, 4 cases of pharyngeal hyperemia, 2 cases of fever (body temperature> 37.3 ℃), no muscle joint pain performance; 9 cases of rash, 2 cases of fever as the first symptom . The rash lasted 2-8 days, with a median of 6 days. Most of the rashes occurred in the chest and back, with different forms of rashes between adults and children. The positive rate of serum PCR was 45.45% (5/11), the positive rate of saliva was 90.91% (10/11), and the positive rate of urine was 100% (11/11). In the patients with latent infection, the positive rate of serum was 1 , Saliva positive in 1 case, urine positive in 3 cases. Conclusion The symptoms of Zika virus are light and it is more difficult to detect in early stage. It is suggested that blood, saliva and urine should be used for nucleic acid detection at the same time as the basis for diagnosis, and mosquito density control should be done in the active phase of Aedes albopictus to reduce the local transmission risk.