胰岛素样生长因子 (IGFs)在儿童急性白血病治疗过程中会出现相应改变 ,IGFs具有促生长作用 ,体外试验证实对白血病细胞系有剂量相关的促增殖效应。同时 ,具有生物活性的游离IGF I水平始终增高 ,IGFs在儿童白血病的发生、发展中起重要作用 ,其结合蛋白在血清和脑脊液中也会出现不同的变化 ,可作为疾病复发和中枢神经系统白血病的监测指标之一。 Insulin-like growth factors (IGFs) change during the treatment of acute leukemia in children. IGFs have a role in promoting growth. In vitro experiments have shown that the leukemia cell lines have a dose-related pro-proliferative effect. At the same time, the activity of free IGF I always increases, IGFs plays an important role in the occurrence and development of childhood leukemia. The binding proteins also have different changes in serum and cerebrospinal fluid. They can be used as disease recurrence and central nervous system leukemia One of the monitoring indicators.