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目的观察心包腔内留置中心静脉导管引流并灌注足叶乙甙(VP-16)、顺铂(DDP)治疗恶性心包积液的疗效。方法 22例恶性心包积液患者应用中心静脉导管心穿刺置管引流,将VP-16及DDP稀释后注入心包腔内治疗。结果完全缓解(CR)12例,部分解(PR)8例,总有效率(CR+PR)为90.9%,其不良反应主要为轻度消化道反应,患者可耐受。结论该方法简便、安全,有效率高,不良反应低,能有效控制恶性心包积液。
Objective To observe the effect of pericardial catheterization of central venous catheter drainage and perfusion of etoposide (VP-16) and cisplatin (DDP) in the treatment of malignant pericardial effusion. Methods Twenty-two cases of malignant pericardial effusion were treated with catheterization of the central venous catheter and percutaneous drainage of VP-16 and DDP. Results Complete remission (CR) in 12 cases, partial solution (PR) in 8 cases, the total effective rate (CR + PR) was 90.9%, the adverse reactions are mainly mild gastrointestinal reactions, patients can tolerate. Conclusion The method is simple, safe, efficient, low adverse reactions, can effectively control malignant pericardial effusion.